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Clinical Trials for Acute-On-Chronic Liver Failure

• Safety and Tolerability of Hepatocyte-like Cell Therapy for Liver Failure and Small-for-Size Syndrome
• Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial
• National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Phase I Study on Safety and Efficacy of Mesenchymal Stem-Cell (MSC) Therapy in Non-Viral Acute-on-Chronic Liver Failure (ACLF)
• National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial
• Pharmacokinetic Study on G1090N (Nitazoxanide) Capsules in Healthy Volunteers
• National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III Trial
• A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With Overt Hepatic Encephalopathy
• Chinese Phase II Trail of AS1501 in Acute-on-chronic Liver Failure (ACLF) Patients
• A-TANGO Phase 2 Study
• Umbilical Cord-derived Mesenchymal Stem Cell Infusion for Treating ACLF
• Comparison of Efficacy and Safety of Ceftazidime Avibactam Versus Extended Infusions of High Dose Meropenem in Patients of ACLF With Nosocomial Infections.
• Efficacy and Safety of Continuous Infusion of Terlipressin vs Bolus Terlipressin in ACLF Patients With Acute Esophageal Variceal Bleed
• Goal Directed Ammonia Lowering Therapy in Hyperammonemic ACLF Patients With no Overt HE to Reduce Major Adverse Liver Related Outcomes (GOAL Trial)
• Efficacy and Safety of BMSCs (CG-BM1) for ACLF Patients
• Safety and Efficacy of Continuous Infusion of Terlipressin With Norepinephrine Versus Norepinephrine Alone in Improving Outcomes of Acute Kidney Injury in Acute on Chronic Liver Failure With Septic Shock
• Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver Failure
• Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)™
• The Efficacy and Safety of Rifaximin Treatment
• Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF)
• F573 for Injection for the Treatment of Liver Injury/Failure
• The Renal Safety of Tenofovir Alafenamide in HBV-related Acute-on-chronic Liver Failure: Real-World Study
• 20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension
• Efficacy and Safety of Avatrombopag for Treating TCP in HBV-ACLF Patients Receiving ALSS Treatment
• Acute Hemodynamic Response to Carvedilol in Predicting Survival in Acute on Chronic Liver Failure Patients - A Pilot Study.
• Intravenous NAC Use in ACLF Patients
• TAK-242 in Patients With Acute Alcoholic Hepatitis
• Efficacy of Albumin Plus Midodrine v/s Albumin Alone in Reducing Incidence of Paracentesis Induced Circulatory Dysfunctions in ACLF Patients.
• Efficacy of Addition of Fecal Microbiota Transplant (FMT) and Plasma Exchange to Tenofovir in Comparison to Monotherapy With Tenofovir in ACLF-HBV
• Efficacy of Early Terlipressin Plus Albumin Therapy in Comparison to Standard Treatment for HRS-AKI in Acute-on-chronic Liver Failure.
• Use of HA 330-II for Hemofiltration in Patients With ALF as a Bridge to Liver Transplantation .
• Intravenous Branched Chain Amino Acids for Hepatic Encephalopathy in ACLF
• Study to Evaluate the Efficacy and Safety of HepaStem in Patients With Acute on Chronic Liver Failure (ACLF)
• Plasma Exchange in Acute on Chronic Liver Failure
• Efficacy and Safety of Hemoperfusion or Plasma Exchange Compared to Standard Medical Therapy in Patients With Acute on Chronic Liver Failure
• PEG3350 in ACLF With Hepatic Encephalopathy
• Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF
• TRimetazidine for acUte on Chronic Liver Failure STudy
• The Efficacy and Safety of Nucleos(t)Ide Analogues in the Treatment of HBV-related Acute-on-chronic Liver Failure
• Study on the Optimal Strategy for Acute-on-chronic Liver Failure With Integrative Treatment
• To Assess the Efficacy of High-Volume Plasma Exchange and GCSF Versus GCSF Alone in Patients of Acute on Chronic Liver Failure (ACLF).
• Transfer Factor Efficacy in the Management of Cirrhosis-associated Immune Dysfunction
• UC-MSC Infusion for HBV-Related Acute-on-Chronic Liver Failure
• To Study the Influence of GCSF on Natural History of Acute On Chronic Liver Failure After the Acute Phase
• High Volume Plasma Exchange in Children With Acute Liver Failure and Acute on Chronic Liver Failure
• To Study the Immunomodulating Effects and Safety Profile of ω3 and ω6 PUFA Containing Intravenous Lipid Emulsion in Patients With Acute on Chronic Liver Failure
• Randomized Controlled Trial Comparing the Efficacy and Safety of FMT in Hepatitis B Reactivation Leads to Acute on Chronic Liver Failure.
• Granulocyte Colony Stimulating Factor (G-CSF) to Treat Acute-on-chronic Liver Failure
• Efficacy of Nonselective Beta Blocker vs Placebo in Patients With Acute-on-chronic Liver Failure With Small/ no Esophageal Varices
• To Compare the Response Rate of Noradrenaline vs. Terlipressin in Hepatorenal Syndrome in Patients With Acute on Chronic Liver Failure
• Incidence And Outcome Of Paracentesis Induced Circulatory Dysfunction In Acute-On-Chronic Liver Failure.
• Effect of Goal Directed Ammonia Lowering Therapy in Acute on Chronic Liver Failure Patients With Hepatic Encephalopathy.
• Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF
• A Trial of Ribavirin in Patients With ACLF Due to Hepatitis E Virus
• Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure
• Randomized Controlled Trial of Tenofovir in Patients of Reactivation of Hepatitis B Presenting as Acute on Chronic Liver Failure
• Granulocyte Colony Stimulating Factor(G-CSF) Therapy for Patients With ACLF