Efficacy of Nonselective Beta Blocker vs Placebo in Patients With Acute-on-chronic Liver Failure With Small/ no Esophageal Varices

• Status: Completed
• Trial end date: 2017-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Acute on chronic liver failure patients with HVPG (Hepatic Venous Pressure Gradient) ≥ 12 mmHg + No/small esophageal varices who present to the Department of Hepatology at Institute of Liver and Billiary Sciences, who meet the inclusion criteria and who provide informed consent.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Institute of Liver and Biliary Sciences, India
• Treatments: Adrenergic beta-Antagonists; Carvedilol

Criteria

Inclusion Criteria:

1. Acute on Chronic Liver Failure as per APASL (Asian Pacific Association of Study of Liver Disease) criteria.

2. 18-75 years

3. HVPG ≥ 12 + No/Small Esophageal varices

Exclusion Criteria:

1. Bradycardia (HR < 60/ min)

2. Hypotension

3. Asthma

4. LVF

5. AKI (Acute Kidney Injury), (S.creat >1.5)

6. Refractory ascites

7. SBP (Spontaneous Bacterial Peritonitis)

8. Pregnancy or Lactation

9. Past history of EVL or EST

10. Significant cardio - pulmonary co-morbidity

11. PVT

12. Presence of grades 3-4 hepatic encephalopathy (HE)

13. Patients going for liver transplant in next 12 weeks

14. No consent