suPAR to Guide Antibiotics in Emergency Department
Status:
Recruiting
Trial end date:
2021-08-31
Target enrollment:
Participant gender:
Summary
The aim of the current study is to evaluate suPAR - guided medical intervention, consisting
of early antibiotic administration at the emergency room for presumed infection and sepsis
and evaluate the impact of this intervention to the patients' final outcome. Since the
traditionally used biomarkers (PCT, CRP) and scores (SOFA score) for early recognition of
severity of infection fail to achieve maximum accuracy in all cases, suPAR levels are
assessed as a probably better prognostic rule for early recognition of severe infections. The
primary study endpoint will be the comparative efficacy of the early suPAR-guided
administration of antibiotics versus standard practice on 28-day mortality.