rTMS of Limbic Circuitry in Stress Modulation in Healthy Volunteers
Status:
Not yet recruiting
Trial end date:
2023-12-31
Target enrollment:
Participant gender:
Summary
This study will be conducted with healthy male and female participants. Aim 1 will determine
during sham repetitive transcranial magnetic stimulation (rTMS) how a drug stressor
combination (yohimbine + hydrocortisone) relative to placebo alters : (1a) impulsivity; (1b)
mood; and (1c) physiology. Aim 2 will determine whether active rTMS over the medial
prefrontal cortex alters the effects of stress-exposure on (2a) decision-making, (2b) mood,
and (2c) biomarkers of stress.