"The Role of the Liver for Interorgan Metabolic Crosstalk in Type 2 Diabetes"

• Status: Unknown status
• Trial end date: 2021-02-20
• Target enrollment: 0
• Participant gender: All

Summary

WP 1: Working hypothesis: The gluconeogenic flux rates from pyruvate (lactate, alanine) and glycerol are higher in patients with T2D compared to the healthy control group.

WP2: Working Hypothesis: The gluconeogenic flux rates of lactate and glycerol are reduced in patients with T2D by acute inhibition of the redox shuttle.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: German Diabetes Center
• Collaborator: Prof. Dr. Gerald Shulman, Yale University, New Haven, Conneticut, USA
• Treatments: Metformin

Criteria

Inclusion Criteria:

• T2D + metformin therapy

• healthy volunteers

Exclusion Criteria:

• no metformin therapy