"Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat

• Status: Completed
• Trial end date: 2004-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This study compares four treatments to see which one causes the most weight loss, fat loss, loss of abdominal fat and improvement in blood tests like cholesterol. The four treatments are: Placebo, Ephedrine plus caffeine, Pioglitazone, Combined pioglitazone and ephedrine plus caffeine

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Pennington Biomedical Research Center
• Treatments: Caffeine; Ephedrine; Pioglitazone; Pseudoephedrine

Criteria

Inclusion Criteria:

• generally healthy

• not pregnant or nursing

• using adequate contraception

• between 18 and 50 years of age

• BMI between 30 and 35 kg/m2

Exclusion Criteria:

• significant renal, cardiac, liver, lung or neurological disease

• high blood pressure

• diabetes

• prior use of thiazolidinedione

• prior use of beta-blockers alcohol or drug abuse

• history of thrombophlebitis, vascular or blood clotting disorders

• unwilling or unable to abstain from caffeinated beverages and alcohol prior to adipose tissue biopsy and metabolic rates measurements

• increased liver function test at baseline

• have metal objects that would interfere with the measurement of the body composition

• use drugs known to affect lipid metabolism, energy metabolism or body weight

• use herbal supplements containing ephedrine and/or caffeine

• take chronic medication, except hormone replacement or contraception

• are a woman unwilling to use effective contraception during the trial

• have heart disease or history of stroke

• have urinary symptoms from enlarged prostate

• have gained and or lost more than 10 pounds in the last 6 month

• have use a monoamine oxidase inhibitor medication in the last month

• have high or low thyroid function that has not been controlled in the normal range for at least 2 months