n-3 Polyunsaturated Fatty Acids in Obesity

• Status: Completed
• Trial end date: 2016-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Inflammation in the adipose (fat) tissue is an important condition leading to metabolic derangements and cardiovascular disease in obese patients. n-3 polyunsaturated fatty acids exert anti-inflammatory effects and prevent adipose tissue inflammation in rodent obesity. This study tests the hypothesis that n-3 polyunsaturated fatty acids ameliorate adipose tissue inflammation in morbidly obese patients.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical University of Vienna
• Collaborator: National Bank of Austria

Criteria

Inclusion Criteria:

• Non-diabetic morbidly obese patients (BMI > 40 kg/m2) supposed to undergo bariatric surgery

• Age 20-65 yrs

Exclusion Criteria:

• Acute illness within the last two week

• Known diabetes mellitus or current anti-diabetic medication

• Acquired immunodeficiency (HIV infection)

• Hepatitis or other significant liver disease

• Severe or untreated cardiovascular, renal, pulmonary disease

• Untreated or inadequately treated clinically significant thyroid disease

• Anemia

• Active malignant disease

• Inborn or acquired bleeding disorder including warfarin treatment

• Pregnancy or breast feeding

• Drug intolerability that prohibits the use of the study drug