Brain scans can help identify changes that appear to increase risk for cognitive decline and
dementia. Some of these brain changes are thought to reflect actual damage to the small blood
vessels that support normal brain function. This clinical trial will determine whether an
omega 3 polyunsaturated fatty acid (PUFA) therapy can promote brain health by supporting the
small blood vessels in the brain over 3 years in older adults at high risk for cognitive
decline and dementia of Alzheimer's type.