μ-opioid Receptor Polymorphism and Opioid Analgesia

• Status: Completed
• Trial end date: 2017-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

In this prospective observational double-blind study, the investigators aim to assess the effect of the single nucleotide polymorphism of the μ-opioid receptor gene (OPRM1, p.118A/G) on the duration of epidural fentanyl labor analgesia.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: American University of Beirut Medical Center
• Treatments: Analgesics, Opioid; Fentanyl

Criteria

Inclusion Criteria:

• Nulliparous parturients ≥ 37 weeks gestation, with ASA I or II, with an uncomplicated course of singleton vertex pregnancy (in spontaneous labor or with spontaneous rupture of membrane), requesting epidural analgesia for pain relief

Exclusion Criteria:

• Advanced cervical dilation (> 5 cm) at the time of request for epidural analgesia

• Severe medical or obstetric complications (preeclampsia, uncontrolled pregestational diabetes, etc…)

• Multiple gestation

• Contraindication to epidural analgesia

• Local anesthetics or fentanyl allergy

• History of chronic opioid use or recent acute opioid use.