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Clinical Trials for Lymphatic Abnormalities

• A Phase 2 Study of Mutant-selective PI3K Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation
• Different Doses of Sirolimus for the Treatment of Cystic Lymphatic Malformations
• Use of Bleomycin in the Sclerotherapy of Lymphatic Malformations for Pediatric Patients
• SELVA: A Phase 3 Study Evaluating QTORIN 3.9% Rapamycin Anhydrous Gel in the Treatment of Microcystic Lymphatic Malformations
• A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations
• Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation.
• Study Evaluating the Safety and Efficacy of PTX-022 (QTORIN Sirolimus) in the Treatment of Microcystic Lymphatic Malformations
• A Pharmacokinetic, Pharmacodynamic, Safety and Tolerability Study of CERC-006 in Adults With Complex Lymphatic Malformations
• Percutaneous Administration of Sirolimus in the Treatment of Superficial Complicated Vascular Anomalies
• Weekly Sirolimus Therapy
• First in Human Trial of Topical VT30 in Pts With Venous/Lymphatic Malformations Assoc With PIK3CA or TEK Gene Mutations
• TOPical Sirolimus in linGUal Microcystic Lymphatic Malformation -TOPGUN
• Topical Sirolimus in Cutaneous Lymphatic Malformations
• OK432 (Picibanil) in the Treatment of Lymphatic Malformations
• Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations
• Sildenafil for the Treatment of Lymphatic Malformations
• A Study to Evaluate Sildenafil for the Treatment of Lymphatic Malformations
• Selenium in the Treatment of Complicated Lymphatic Malformations
• Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies
• Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic Malformations