mFOLXOX6 Versus FOLFIRI for Colorectal Patients Recurrence After Oxaplatin Based Adjuvant Chemotherapy
Status:
Recruiting
Trial end date:
2023-12-31
Target enrollment:
Participant gender:
Summary
A multicenter,open,prospective randomized controlled trial;11 study center in China; Plan to
enroll 328 patients（ Power Analysis and Sample Size ）.Comparing FOLFIRI with
mFOLFOX6,Superiority design.Investigate difference PFS,ORR,R0 resection rate,OS ,QoL and
Safety from two regimens Stratification factors : Analyzing patients recurrence within
6-12months,and 12-18months .Obtain definite chemotherapy regimen shift opportunity for
patients recurrence/metastasis after adjuvant chemotherapy.
Phase:
Phase 3
Details
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University