iPACK Block With Dexamethasone For Total Knee Replacement

• Status: Not yet recruiting
• Trial end date: 2022-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Comparing the pain control outcomes for patients undergoing total knee arthroplasty (TKA) with either: 1) adductor canal single shot injection plus placebo iPACK injection or 2) adductor canal single shot injection plus bupivacaine and dexamethasone iPACK injection.

There are two surgical approaches for TKA 1) open 2) ROSA robotic assisted. Both follow the same pain management pathway. We plan to enroll patient undergoing either surgical procedure.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of California, San Diego
• Treatments: Dexamethasone; Epinephrine; Ropivacaine

Criteria

Inclusion Criteria:

• Having total knee arthroplasty at UC San Diego

• Plan to receive single shot adductor canal injection preoperatively

• Plan to receive spinal anesthetic with or without sedation for TKA surgery

Exclusion Criteria:

• Pregnancy

• Inability to communicate with anesthesia provider and/or investigators

• Severe renal, hepatic, cardiac disease

• Chronic high-dose opioid use (defined as daily use for more than 4 weeks prior to surgery of at least the equivalent of 20 mg oxycodone)

• BMI > 45 kg/m2

• Allergy to study medications (lidocaine, bupivacaine)

• Incarceration