β-blockers Withdrawal in Patients With HFpEF and Chronotropic Incompetence: Effect on Functional Capacity (Preserve-HR)
Status:
Completed
Trial end date:
2021-02-27
Target enrollment:
Participant gender:
Summary
The pathophysiology of heart failure with preserved ejection fraction (HFpEF) is complex and
multifactorial. Chronotropic incompetence has emerged as a crucial mechanism, particularly in
elderly patients. Betablockers, drugs with negative chronotropic effect, are commonly used in
HFpEF, despite current evidence does not support its routine use in these patients. The aim
of this work is to evaluate the effect of betablockers withdrawal in patients with HFpEF and
chronotropic incompetence on functional capacity assessed by the peak oxygen consumption at
maximal exercise (peakVO2) at 15 and 30 days after the intervention
Phase:
Phase 4
Details
Lead Sponsor:
Fundación para la Investigación del Hospital Clínico de Valencia