Introduction: The prevalence of chronic insomnia in the general population is between 10 and
15%. The therapy commonly prescribed for its treatment is pharmacological, however, there are
several non-pharmacological alternatives being studied, among them physical exercise.
Although some studies have described the effect of exercise on sleep in insomnia, there are
no studies comparing exercise and drugs in the treatment of chronic insomnia, or its effect
as coadjuvant therapy.
Objective: To compare the acute and chronic effects of aerobic exercise and zolpidem on sleep
quality, mood and quality of life in patients with chronic insomnia.
Material and Methods: 30 patients with chronic insomnia will be randomly assigned into two
groups: EXERCISE (n=15) or ZOLPIDEM (n=15). The patients of EXERCISE group will be included
in an aerobic exercise program, performed in 50% of reserve heart rate, on a treadmill (50
minutes, 3 times/week), during 6 weeks. The ZOLPIDEM group will be treated with zolpidem
(10mg/night) during 6 weeks. Polysomnography, actigraphy, sleep diary and questionnaires will
be used the evaluate sleep pattern. Mood and quality of life will be investigated by POMS and
SF-36 questionnaires.
Hypothesis: Considering previous studies have demonstrated positive effects of aerobic
exercise in the insomnia symptoms, the hypothesis of this study is that aerobic exercise,
performed at moderate intensity, can control the symptoms of chronic insomnia similarly to
pharmacological therapy.