Zinc Supplementation in Children With Sickle Cell Disease in Western Kenya
Status:
Completed
Trial end date:
2017-01-19
Target enrollment:
Participant gender:
Summary
Zinc is a nutritionally essential trace element found in previous studies to reduce growth
retardation and improve immune function, which may also result in decreased incidence of
infectious diseases including malaria, pneumonia and diarrhea. Sickle Cell Disease (SCD)
patients are known to be susceptible to zinc deficiency and appear to benefit from zinc
supplementation. The proposed pilot research project aims to investigate the influence of
zinc supplementation on incidence of malaria infections, incidence of bacterial infections
and investigate the influence of zinc supplementation on morbidity in children with SCD in
western Kenya. The differences in incidence of morbidity and other secondary endpoints will
be compared between the zinc group and the control group.
Phase:
N/A
Details
Lead Sponsor:
Lucas Otieno Tina, MD MSc
Collaborators:
GlaxoSmithKline Strathmore University
Treatments:
Folic Acid Hydroxyurea Penicillin V Penicillins Proguanil Zinc Zinc Sulfate