ZYNRELEF for Pain Management in Total Knee Arthroplasty
Status:
Not yet recruiting
Trial end date:
2026-04-01
Target enrollment:
Participant gender:
Summary
The goal of this randomized controlled trial is to compare opioid medication consumption
after surgery for patients who have a total knee replacement.
The main questions it aims to answer are:
- How well does the study drug control pain in the days after surgery?
- Does the study drug reduce the amount of opioid analgesic consumed after surgery?
Participants in the study group will undergo a total knee replacement as planned with their
surgeon. In addition, be given the study drug, Zynrelef (combination of bupivacaine and
meloxicam).
Researchers will compare the above to a control group who will have a total knee replace only
according to usual standards to see if there are any differences in the amount of a type of
pain medication (opioid analgesic) consumed in the days following surgery.