Xylometazoline and Cocaine for Nasal Vasoconstriction

• Status: Not yet recruiting
• Trial end date: 2023-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to compare xylometazoline and cocaine's effect on minimizing epistaxis when administered as a local vasoconstrictor prior to nasal intubation.

We hypothesize that there will be a lower bleeding score in the group receiving xylometazoline as compared with the group receiving cocaine.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rigshospitalet, Denmark
• Treatments: Cocaine; Xylometazoline

Criteria

Inclusion Criteria:

• Age ≥ 18 years

• Scheduled for nasal intubation

• Proficient in spoken and written Danish

Exclusion Criteria:

• Intubation to be done on awake patient

• Pregnancy

• Women of childbearing potential must produce a negative hCG urine stix to participate

• Known symptomatic coronary artery disease

• As declared by patient or noted in the patient's file

• Untreated hypertension

• As declared by patient or noted in the patient's file

• Not taking antihypertension drugs

• Hypersensitivity to the active substance or to any of the excipients of Zymelin

• As declared by patient or noted in the patient's file

• Closed-angle glaucoma

• As declared by patient or noted in the patient's file