Overview

Xylocaine to Freeze During Unpleasant Nasopharyngeal Swabs

Status:
Completed
Trial end date:
2021-06-07
Target enrollment:
0
Participant gender:
All
Summary
Since the beginning of the COVID-19 pandemic, nasopharyngeal swabs (NPS) have been recommended to detect the virus. This procedure has been reported to be painful by 85% of children The aim of the study was to assess whether pretreatment with topical lidocaine reduces the discomfort experienced by children during a nasopharyngeal swab. This was a RCT among children aged 8-17 years old who need a NPS. The primary outcome was pain intensity as measured by the Visual Analog Scale .
Phase:
Phase 2/Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Evelyne D.Trottier
Treatments:
Lidocaine
Criteria
Inclusion:

- 6-17 years old inclusively

- Children for whom a NPS was ordered

Exclusion:

- Children presenting with the following acute conditions, which could either prevent
the lidocaine from being properly administered, or pose a risk for the patient as
increased absorption of the medication might occur:

- Nasal or airway burns, trauma or major anomaly

- Cardiorespiratory compromise

- Children for whom an informed consent could not be obtained

- Any other life-threatening condition or priority one patient requiring emergency
support

- Language barrier

- Children presenting with conditions that could prevent their ability to reliably
report their pain:

- Severe intellectual disability

- Severe pain upon presentation

- Administration of opiates prior to the NPS

- Children presenting with the following chronic conditions, which could either prevent
the lidocaine from being properly administered, or pose a risk for the patient:

- Hypersensitivity/allergy to the medication or a known component

- Methemoglobinemia

- G6PD deficiency

- Familial malignant hyperthermia

- Pseudocholinesterase deficiency

- Severe hepatic impairment

- Severe cardiac condition or use of antiarrhythmic medication

- Risk of airway aspiration