Xylitol Versus Saline in Chronic Sinusitis

• Status: Completed
• Trial end date: 2014-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Is a xylitol nasal rinse better or worse than saline on patient satisfaction.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Iowa

Criteria

We now have two arms to this study.

Group I: Immunocompetent subjects with chronic rhinosinusitis

Inclusion Criteria:

• 56 Adult subjects (18 or older) presenting to the ENT(ears, nose, throat) clinics who meet the diagnosis of chronic rhinosinusitis (CRS). Definition of CRS: Presence of at least 2 of the following 4 signs/symptoms for 12 weeks or longer despite medical management:

• Anterior and/or posterior mucopurulent drainage

• Nasal obstruction

• Facial pain, pressure, and/or fullness

• Decreased sense of smell

• In addition, objective evidence of sinus mucosal disease must be demonstrated on sinus CT imaging or direct endoscopic examination.

Exclusion Criteria:

• Cystic fibrosis

• Fungal sinusitis

• Immunocompromised status (use of long term oral steroids (> 30 days), AIDS, active malignancy or chemotherapy)

• Known Ciliary disorders

• Sinonasal tumors

• Pregnancy

Group 2: CRS with antibody deficiency

• 56 Adult subjects (18 or older) presenting to the Allergy clinic who meet the diagnosis of chronic rhinosinusitis (CRS). Definition of CRS: Presence of at least 2 of the following 4 signs/symptoms for 12 weeks or longer despite medical management:

• Anterior and/or posterior mucopurulent drainage

• Nasal obstruction

• Facial pain, pressure, and/or fullness

• Decreased sense of smell

• In addition, objective evidence of sinus mucosal disease must be demonstrated on sinus CT imaging or direct endoscopic examination.

Exclusion criteria:

Cystic Fibrosis Sinonasal tumors Pregnancy