Xerostomia in Patients With a Life-limiting Condition or Frailty
Status:
Not yet recruiting
Trial end date:
2025-06-01
Target enrollment:
Participant gender:
Summary
Xerostomia, the subjective feeling of dry mouth, is a common symptom during the last year of
life in patients with a life-limiting condition or frailty. Xerostomia leads to functional
alterations (such as burning sensations, an altered taste perception, and difficulties with
chewing, swallowing, and speaking), has disabling social consequences and significantly
downgrades the perceived quality of life. It is an under-exposed and under-treated symptom
often caused by alterations in the quality and quantity of saliva.
Locally administered pilocarpine could be a promising drug in this regard as it alleviates
xerostomia by increasing the production of saliva.
Phase:
Phase 3
Details
Lead Sponsor:
Maastricht University Medical Center
Collaborator:
ZonMw: The Netherlands Organisation for Health Research and Development