Xenon in Off-pump Coronary Artery Bypass Graft Surgery

• Status: Completed
• Trial end date: 2014-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Purpose of this study is to test whether xenon application during off-pump-coronary artery bypass (OPCAB)-surgery is safe and feasible.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universitaire Ziekenhuizen Leuven
• Treatments: Anesthetics; Sevoflurane; Xenon

Criteria

Inclusion Criteria:

• Patients with coronary artery disease scheduled for elective OPCAB- surgery

• Patients willing and able to complete the requirements of this study

• Ejection Fraction > 30%

Exclusion Criteria:

• Lack of informed consent

• Age < 18 years

• Pregnancy

• chronic obstructive pulmonary disease (COPD) GOLD > II

• Renal dysfunction defined as serum-creatinine > 1.5 mg/dl

• Acute coronary syndrome during the last 24 hours; haemodynamic instability, requirement of inotropic support

• Single vessel grafting

• Disabling neuropsychiatric disorders (severe dementia, Alzheimer's disease, schizophrenia, depression), history of stroke with residuals, significant stenosis of carotid arteries, increased intracranial pressure

• Hypersensitivity to the study medication

• Presumed uncooperativeness or legal incapacity