Xenon as an Adjuvant to Propofol Anaesthesia in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery.

• Status: Completed
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators hypothesize that the application of 30% xenon as an adjuvant to general anesthesia with a target-controlled infusion of propofol is superior to general anesthesia with propofol alone with respect to hemodynamic stability.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universitaire Ziekenhuizen Leuven
• Treatments: Anesthetics; Propofol; Xenon

Criteria

Inclusion Criteria:

• patients with coronary artery disease scheduled for elective OPCAB-surgery

• patients willing and able to complete the requirements of this study

• Ejection fraction >30%

Exclusion Criteria:

• Lack of informed consent

• age < 18 years

• COPD GOLD >II

• Renal dysfunction defined as serum-creatinine >1.5mg/dl

• acute coronary syndrome during the last 24 hours; haemodynamic instability, requirement of inotropic support

• single vessel grafting

• disabling neuropsychiatric disorders (severe dementia, Alzheimer's disease, schizophrenia, depression, low preoperative cognitive state (MMSE at baseline <25), history of stroke with residuals, increased intracranial pressure

• Hypersensitivity to the study medication

• Presumed uncooperativeness or legal incapacity