Xenon-anesthesia on Patients Undergoing Major Liver-resection

• Status: Withdrawn
• Trial end date: 2019-09-27
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to compare the postoperative outcome of patients undergoing major liver resection under xenon- compared to desflurane-anesthesia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: RWTH Aachen University
• Treatments: Anesthetics; Benzocaine; Desflurane; Isoflurane; Xenon

Criteria

Inclusion Criteria:

• ≥ 3 segments liver resection

• ≥ 18 years

• Both gender

• American Society of Anesthesiologists (ASA) classification I-III

• Written informed consent prior to study participation

Exclusion Criteria:

Subjects, fulfilling one or more of the following exclusion criteria will not be included in the study:

• Severe pulmonary or airway disease

• Severe liver disease, accompanied by a Child-Pugh class >A

• Allergy/hypersensitivity to study medications

• ASA ≥ IV

• Patients susceptible to malignant hyperthermia

• Women who are pregnant, breast-feeding or women of childbearing potential not using adequate contraceptive methods

• Patients with preeclampsia or eclampsia

• Patients legally unable to give written informed consent.

• Patients with risk of high oxygen demand

• Patient with seriously impaired cardiac function

• All contraindications for xenon anesthesia according to the summary of product characteristics LENOXe

• Patient participates in a parallel interventional clinical trial during this study or receives an investigational drug within 30 days prior to inclusion into this study