XILO-FIST, the Effect of Allopurinol on the Brain Heart and Blood Pressure After Stroke
Status:
Unknown status
Trial end date:
2021-02-01
Target enrollment:
Participant gender:
Summary
Recurrent stroke and cognitive decline are common after ischaemic stroke. Allopurinol, a drug
usually used to treat gout, has been shown to reduce heart ischaemia, heart size, and
arterial stiffness and to relax brain blood vessels and may reduce the blood pressure. All of
these properties may be associated with a lower risk of second stroke and cognitive decline.
We now aim to explore whether allopurinol will reduce further damage to the brain (called
white matter hyper-intensities) after stroke and also whether it reduces heart size and blood
pressure after stroke.
We will conduct a multi-centre randomised, double-blind placebo controlled study to
investigate whether two years allopurinol 300 mg twice per day (BD) improves these 3
outcomes, which are inextricably linked to risk of recurrence and cognitive decline after
ischaemic stroke.