Wound Infections in Breast Cancer Surgery After Preoperative Skin Preparation With Chlorhexidine vs. Povidone-iodine
Status:
Completed
Trial end date:
2016-09-01
Target enrollment:
Participant gender:
Summary
The development of surgical site infections (SSI) in clean-contaminated surgery is regarded
as being preventable. Known to be effective in the prevention of surgical site infection are
the adequate sterilization of the surgical instruments, asepsis during operation, antibiotic
prophylaxis where indicated, and certainly the preparation of the skin at the incision site,
since the patient's skin is the principal source of bacterial contamination of the wound.
This study aims to investigate the efficacy in prevention of surgical site infection in clean
surgery, using two different standardized methods of skin preparation: povidone-iodine 10%
aqueous solution from 1.5 liter bulk bottle, versus tinted 2% chlorhexidine in 70% isopropyl
alcohol in a single-dose applicator. To reduce the variables involved, a single-center study
will enroll a homogeneous population, undergoing breast cancer surgery.
Phase:
Phase 4
Details
Lead Sponsor:
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano