Withdrawal of Etanercept After Successful Treatment of Juvenile Idiopathic Arthritis
Status:
Unknown status
Trial end date:
2013-09-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine whether etanercept can be withdrawn successfully
(i.e. no occurrence of flares) in juvenile idiopathic arthritis (JIA) patients in whom
disease remission is reached.
Goals:
1. to investigate in a randomized controlled trial:
- which proportion of JIA patients in remission can successfully discontinue
etanercept compared to JIA patients in remission who continue etanercept;
- if time in remission on etanercept is an important factor in retaining remission
after discontinuation of etanercept.
2. to investigate in alle JIA patients who discontinue etanercept (including the control
group):
- predicting factors (patient or disease characteristics, including time in
remission, and MRP8/MRP14) for successfully discontinuation of etanercept;
- the disease course after discontinuation of etanercept (time to flare) and the
effect of restarting etanercept after flaring.