Window of Opportunity Study Targeting the Inflammatory Milieu
Status:
Active, not recruiting
Trial end date:
2021-10-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate the effect of two anti-inflammatory drugs, fish oil
capsules and the COX-2 inhibitor celecoxib, on pregnancy associated breast cancer (PABC).
Short-term intervention with anti-inflammatory medications will demonstrate a reduction in
the inflammation and immune suppressive phenotype of PABC, and decreased metastatic potential
in PABC. This unique window in breast cancer management serves as a valuable opportunity to
obtain preliminary data on biomarkers and the alterations that occur when the system is
troubled by a drug or other intervention which will be instrumental in designing future
therapeutic or preventative strategies for larger clinical study.