The purpose of this study is to find out differences in activation of mood regulating areas
of the brain in response to negative and positive pictures, before and after 6 weeks of
additional Wellbutrin XL treatment. Participants should have been treated for depression with
an SSRI medication (e.g., Prozac, Zoloft, Paxil, Celexa or Lexapro) and have decreased
depression symptoms but also be experiencing side effects of medications such as sexual side
effects and feelings of apathy (indifference, lack of interest) and lack of full emotional
response. We will first take a brain scan to measure activity in different parts of the
brain, while subjects are seeing pictures, using Magnetic Resonance Imaging (MRI) scan. Then
we will add Wellbutrin XL - another well-known antidepressant that acts by increasing the
chemical dopamine in the brain, to subjects' treatment. Wellbutrin addition is useful in
decreasing the sexual side effects of SSRIs. After treatment with Wellbutrin XL for 6 weeks
subjects will have a second MRI scan with picture rating.