The purpose of this study is to evaluate the safety and efficacy of oral weekly
glucocorticoid steroids in patients with Becker Muscular Dystrophy (BMD), an inherited
disorder in which patients experience weakness of the legs and pelvis, and Limb Girdle
Muscular Dystrophy (LGMD), an inherited disorder in which patients experience progressive
muscular weakness predominately in their hip and shoulders. The primary objective is safety
which we the investigators will measure using laboratory testing and forced vital capacity
(FVC), a breathing test that measures the strength of your lungs. The secondary objective is
efficacy which will be measured by a change in MRI muscle mass, improved muscle performance,
and quality of life.
The investigators hypothesize that patients who receive oral weekly glucocorticoid steroids
will have improviements in strength and quality of life compared to their baseline.
Furthermore, the investigators anticipate that oral weekly glucocorticoid steroids will not
have significant adverse impact on patients.