The study team will determine the potential of low dose weekend prednisone and whether
exercise training can synergize to delay disease progression and improve muscle
strength/physical function in boys with Duchenne muscular dystrophy (DMD). Current standard
of care (daily prednisone) is associated with adverse side effects. Evidence from DMD mouse
models suggest that weekend dosing provides same efficacy without side effects. Appropriate
exercise may also benefit but this area has not been adequately explored.
Phase:
Phase 2
Details
Lead Sponsor:
University of Florida
Collaborator:
U.S. Army Medical Research and Development Command