Wearing-Off Period of Pharmacological Dilation and Anisocoria
Status:
Not yet recruiting
Trial end date:
2024-03-01
Target enrollment:
Participant gender:
Summary
Students at the School of Medicine Greenville will be asked to participate in this study.
The aim of this study is to better understand when medical imaging is needed for patients
with anisocoria (unequal pupil size).
Participation in the study includes 3 visits over a period of 2 days. Each study visit will
last about 30 minutes.
At the first visit, participants will be screened for hyperopia, have their intraocular
pressures taken, and have their iridocorneal angle measured using gonioscopy at the
ophthalmology clinic. Proparacaine hydrochloride 0.5% eye drops will be used to numb the eyes
before measuring intraocular pressures and prior to gonio lens exam. Participants will also
be asked to complete three forms.
Participants will be asked to return to the clinic the next day to have their left eye
dilated. At this visit, the diameter of the pupil will be measured using a Near card in a
windowless room with a set light-level. Then, the participant will receive one drop of
tropicamide in the left eye. After the drops have had time to take effect, which will be
about 20-30 minutes later, the diameter of the pupil will be measured again.
Participants will then be asked to return to the clinic in 3-4 hours. At this time, we will
record the diameter of the pupil again.
The third type of eye drop used in this study is 1% pilocarpine. 1 % pilocarpine will briefly
constrict the eyes. One drop of 1% pilocarpine will be administered to left eye, and the
change in pupillary diameter will be measured, if any.
Participants may be required to attend 2 additional 30-minute visits on a third day depending
on how their eyes respond to the drops.
This study will recruit about 10-15 participants.