Warfarin in Preventing Blood Clots in Cancer Patients With Central Venous Catheters

• Status: Completed
• Trial end date: 2009-02-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Warfarin may be effective in preventing the formation of blood clots in patients with central venous catheters.

PURPOSE: Randomized clinical trial to study the effectiveness of warfarin in preventing blood clots in cancer patients who have central venous catheters.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cancer Research Campaign Clinical Trials Centre
• Treatments: Warfarin

Criteria

DISEASE CHARACTERISTICS:

• Histologically or cytologically confirmed cancer

• Planned placement of central venous catheter (CVC) for administration of chemotherapy

• No use of CVC for additional purposes except for antibiotic therapy or blood products

PATIENT CHARACTERISTICS:

Age:

• 16 and over

Performance status:

• Not specified

Life expectancy:

• Not specified

Hematopoietic:

• WBC at least 2,000/mm3

• Platelet count at least 100,000/mm3

• Hemoglobin at least 10 g/dL

• No congenital bleeding disorders

Hepatic:

• Not specified

Renal:

• Not specified

Other:

• No contraindication to warfarin

• No anatomic lesions that bleed (e.g., duodenal ulcers)

• Not pregnant or nursing

• Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy

• Not specified

Chemotherapy

• See Disease Characteristics

Endocrine therapy

• Not specified

Radiotherapy

• Not specified

Surgery

• Not specified

Other

• No prior enrollment on this study

• No concurrent therapy that would interfere with study drug

• No concurrent warfarin