Voxelotor CYP and Transporter Cocktail Interaction Study
Status:
Completed
Trial end date:
2023-10-04
Target enrollment:
Participant gender:
Summary
This research study is examining multiple doses of voxelotor (a study drug intended for
treatment of sickle cell disease) and how it interacts with additional substrates (substrates
are drugs or other substances that are metabolized by cytochrome enzymes. The substrates used
in this study are FDA approved medications). The study will help to determine the safety and
tolerability of the study drugs taken together, as well as the pharmacokinetics (PK) on how
your body processes and responds to the combination of the study drug and substrates.
Although these drugs are FDA approved, their use in this study is experimental.