Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas
Status:
Active, not recruiting
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
This phase I trial is studying the side effects and best dose of vorinostat when given
together with temozolomide in treating patients with malignant gliomas. Drugs used in
chemotherapy, such as vorinostat and temozolomide, work in different ways to stop the growth
of tumor cells, either by killing the cells or by stopping them from dividing. Vorinostat may
also stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Vorinostat may help temozolomide work better by making tumor cells more sensitive to the
drug. Giving vorinostat together with temozolomide may kill more tumor cells.