Vorinostat, Bortezomib and Dexamethasone in Multiple Myeloma (MUKFour)
Status:
Completed
Trial end date:
2018-08-29
Target enrollment:
Participant gender:
Summary
Bortezomib is an established treatment in multiple myeloma; it is common practice in the UK
to administer bortezomib with dexamethasone. This practice is based on data that supports
improved response rates with this combination.
Recent trial data indicates that the addition of vorinostat to bortezomib treatment overcomes
treatment resistance to bortezomib. As such this current trial is designed to investigate the
efficacy, safety and tolerability of combination treatment with vorinostat, bortezomib and
dexamethasone in patients with relapsed and relapsed refractory myeloma.
A comparison of this Phase II trial with the pivotal Phase III trial conducted by MSD (using
the labelled bortezomib indication without dexamethasone) will address the impact of
dexamethasone in regards to tolerability and additional efficacy in myeloma patients.