Vonoprazan Efficacy to Prevent Post Variceal Band Ligation Ulcer
Status:
Not yet recruiting
Trial end date:
2022-04-30
Target enrollment:
Participant gender:
Summary
Endoscopic variceal ligation (EVL) is used to control and prevent variceal bleeding in
patients with liver cirrhosis, but it can be complicated by bleeding from post-EVL ulcers.
the current study aims at evaluating the potential benefit of different acid-suppressive
therapies in prevention of post band ligation ulcer/bleeding. We will include 234 patients
with cirrhotic portal hypertension undergoing endoscopic band ligation. Patients will be
randomly allocated into one group of acid suppressive therapy (Vonoprazan or pantoprazole)
versus placebo for 14 days. Re-endoscopy will be done after 2 weeks of treatment to assess
the healing of post ligation ulcers. Any form of upper gastrointestinal bleeding will be
documented.