Overview

Volatile Anaesthesia and Perioperative Outcomes Related to Cancer Feasibility Study

Status:
Unknown status
Trial end date:
2020-06-30
Target enrollment:
0
Participant gender:
All
Summary
A multicentre, prospective randomized, active-controlled feasibility trial of volatile-based anaesthesia vs. propofol-based total intravenous anaesthesia to investigate the impact of anaesthesia on long-term (i.e. 5-years) patient cancer outcomes in patients undergoing elective major cancer surgery.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Peter MacCallum Cancer Centre, Australia
Collaborators:
M.D. Anderson Cancer Center
Melbourne Health
The Alfred
Treatments:
Anesthetics
Desflurane
Isoflurane
Propofol
Sevoflurane
Criteria
Inclusion Criteria:

- Male or female

- Age 18-80 years

- Elective surgery

- Major cancer surgery expecting to last two or more hours, for:

- Breast (mastectomy or segmentectomy plus sentinel node dissection)

- Colorectal

- Lung

- Prostate

- Melanoma (excision of melanoma plus lymph node dissection AND/OR skin flap
construction

- Other major cancer surgeries (e.g. oesophagectomy, head and neck cancer, etc.)

Exclusion Criteria

- Palliative surgery for end-stage disease with no curative intent

- Emergency surgery

- Extensive comorbid disease, i.e. American Society of Anesthesiologists (ASA) Score > 4

- Age <18 or >80 years old

- Refusal or inability to provide valid informed consent

- Risk of severe postoperative nausea and vomiting (PONV risk score >3)

- Previous allergy or contraindication to either anaesthetic medication

- Indication for gas induction of anaesthesia

- Currently enrolled in another clinical trial unless agreed by the coordinating
principal investigator and site principal investigator that co-enrolment can occur.