Voice Tremor in Spasmodic Dysphonia: Central Mechanisms and Treatment Response
Status:
Completed
Trial end date:
2017-06-30
Target enrollment:
Participant gender:
Summary
The proposed research aims to determine brain abnormalities in patients with spasmodic
dysphonia (SD) and voice tremor (VT) as the basis for characterization of central mechanisms
underlying symptom improvement following the use of sodium oxybate, a novel oral medication
for the treatment of ethanol-responsive dystonia. The proposed research is relevant to public
health because the elucidation of disorder-specific mechanistic aspects of brain organization
in SD vs. SD/VT is ultimately expected to lead to establishment of enhanced criteria for
clinical management of these disorders, including differential diagnosis and treatment. Thus,
the proposed research is relevant to the part of NIH's mission that pertains to developing
fundamental knowledge that will help to reduce the burdens of human disability.
Phase:
Phase 2
Details
Lead Sponsor:
Kristina Simonyan
Collaborators:
National Institute on Deafness and Other Communication Disorders (NIDCD) National Institutes of Health (NIH)