The investigators hypothesized that in vitamin D deficiency the 25-OH-D3 vitamin substitution
improve the heart function in chronic heart failure.
Type of study: Controlled, randomized, double blind, placebo control
Number of patient: 300; 150 treated and 150 placebo controlled
Type of drug: 180 000 IU 25-OH-D3 vitamin oil (Vigantol) per month in the 0,1,2,3,6, month
Duration of study:1+1 year
Primary end points:
Survival rate, Ejection fraction by ultrasound, Brain natriuretic peptid,
Secondary end points:
Safety of D-vitamin supplementation, well being score, blood pressure, BMI Walking distant in
6 minutes
Visits:
Screening, Randomization, 1month, 2 month, 3 month, 6 month, 12 month, 24 month,