Vitamin E to Prevent Mucositis in Children With Cancer

• Status: Completed
• Trial end date: 2005-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary objective is to determine whether in children undergoing doxorubicin-containing chemotherapy, if topical vitamin E, when compared to placebo, decreases an objective measurement of oral mucositis.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Hospital for Sick Children
• Treatments: alpha-Tocopherol; Tocopherols; Tocotrienols; Vitamin E; Vitamins

Criteria

Inclusion Criteria:

• diagnosis of cancer and treated at the Hospital for Sick Children, Toronto, Canada

• planned chemotherapy includes at least two identical courses of doxorubicin-containing chemotherapy in which the dose of doxorubicin was at least 60 mg/m2 per course

• at least 6 years of age and less than 18 years

• lives in the Greater Toronto area

Exclusion Criteria:

• allergy to vitamin E or placebo ingredients

• child is unable to comply with topical vitamin E application

• cild is receiving head or neck irradiation