Burned patients because of their increased oxidative stress have severely depleted vitamin E,
which is a dietary antioxidant. Oxidative stress is responsible for much of the
pathophysiology seen in burned patients, which leads to acute and chronic morbidity and
mortality, in addition to a decrease in their quality of life. Oral vitamin E will be used to
reverse the oxidative stress of burn injury and, in the process, decrease the secondary
consequences of thermal trauma. This proposal will demonstrate the benefit of maintaining
adequate vitamin E status.
Phase:
Phase 1
Details
Lead Sponsor:
Shriners Hospitals for Children
Collaborators:
Oregon State University University of Texas
Treatments:
alpha-Tocopherol Tocopherols Tocotrienols Vitamin E Vitamins