Overview

Vitamin D for Polycystic Ovary Syndrome Clomiphene Resistant Women

Status:
Completed
Trial end date:
2019-03-30
Target enrollment:
0
Participant gender:
Female
Summary
This study is determining the therapeutic effect of Vitamin D supplements to Pcos clomiphene resistant polycystic ovarian syndrome Women. Half of patients will receive Vitamin D with metformin while other half metformin only. Then both groups start clomiphene for 3 month
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Ain Shams University
Treatments:
Citric Acid
Clomiphene
Enclomiphene
Ergocalciferols
Metformin
Vitamin D
Vitamins
Zuclomiphene
Criteria
Inclusion Criteria:

- Diagnosis of PCOS as defined by the Rotterdam criteria

- Females age 20-35 years old

- BMI 18-30 kg/m2

- 1ry or secondary infertility

- Clomiphene resistant ( patients didn't - show response: ovulate to dose of 200 mg
clomid per day for 3 cycles )

- Willingness to comply with study protocol for 5 months

- Willingness to give written informed consent to participate in the study

Exclusion Criteria:

- Previous metformin intake

- ovarian drilling

- tubal factor as evidenced by hysterosalpingogram or laparoscope

- endometrial pathology ex., polyp

- Myometrial pathology ex., adenomyosis or fibroid

- abnormal semen parameters

- Cushing syndrome

- Hyperprolactinemia

- Adrenal secreting tumor