Overview

Vitamin D as a Key Player in Rheumatoid Arthritis

Status:
Completed

Trial end date:
2021-06-01

Target enrollment:
0

Participant gender:
All

Summary

Rheumatoid arthritis (RA) is a systemic, chronic and inflammatory disease of joints linked to autoimmunity. Vitamin D was found to modulate cell growth, function of immune cells and anti-inflammatory action. The aim of this study was to investigate serum vitamin D level and some cytokines and to identify the correlation between vitamin D and these cytokines in RA. Methods: Totally 60 RA patients without vitamin D supplement were involved in this study. The serum level of vitamin D, interleukin-6 (IL-6), IL-10, IL-35, tumor necrosis factor α (TNF-α) and C-reactive protein (CRP) were measure in all patients by enzyme-linked immunosorbent assay (ELISA) then they will divided into 2 groups, group I receive vit. D supplementation and group II will receive placebo and follow up for 3 months.

Phase:

Phase 3

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Assiut University

Treatments:

Ergocalciferols
Vitamin D
Vitamins

Criteria

Inclusion Criteria:

- RA patients

Exclusion Criteria:

- Patients with inflammatory bowel disease patients with any other autoimmune diseases