Vitamin D as Treatment for Chronic Obstructive Pulmonary Disease (COPD)

• Status: Completed
• Trial end date: 2010-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This project aims to explore the relationship between Vitamin D deficiency and COPD progression via a prospective randomized placebo-controlled study. For this purpose, study was powered to 120 patients hospitalized with an exacerbation of COPD randomly assigned to a monthly oral dose of Vitamin D versus placebo. Taking into account dropouts, 182 patients are randomized during the course of the study

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Katholieke Universiteit Leuven; KU Leuven
• Treatments: Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Primary diagnosis of COPD exacerbation

• Smoking history of at least ten pack years

• GOLD stage II, III and IV as assessed by a post-bronchodilator spirometry

• Informed consent

Exclusion Criteria:

• Tiffeneau index >70% or FEV1 >80%

• Hypercalcemia

• Sarcoidosis

• Newly discovered symptomatic osteoporosis (proven by DEXA and RX )

• Active cancer