Low total testosterone (TT) is present in about 30% of men aged >60 years and in up to 7% of
younger men. Male hypogonadism is associated with metabolic and cardiovascular diseases as
well as with increased mortality. There is evidence showing a relationship of TT with vitamin
D in men. We aim at evaluating the effect of vitamin D supplementation on TT and metabolic
parameters in hypogonadal men. We will study the effects of 20,000 IU vitamin D weekly in a
12 wk randomized, double-blind, placebo-controlled trial in 100 men with TT <3.0 ng/ml and
25-hydroxyvitamin D (25(OH)D) <30 ng/ml (patients) as well as in 100 men with TT ≥3.0 ng/ml
and 25(OH)D <30 ng/ml (controls). Vitamin D supplementation might be a safe therapeutic
approach improving TT levels as well as metabolic parameters in hypogonadal men. Further the
effects of vitamin D on androgens will be evaluated in eugonadal men.
Phase:
Phase 4
Details
Lead Sponsor:
Medical University of Graz
Treatments:
Cholecalciferol Ergocalciferols Vitamin D Vitamins