Vitamin D Supplementation in Chronic Stable Heart Failure
Status:
Completed
Trial end date:
2013-10-01
Target enrollment:
Participant gender:
Summary
In cross-sectional and prospective cohort studies, vitamin D deficiency is associated with
increased mortality, cardiovascular events including sudden cardiac death and stroke,
diabetes, hypertension and impaired function of the immune and musculoskeletal system. The
action of vitamin D on the cardiovascular system regulates cardiac function, endothelial and
vascular smooth muscle, and, the renin-angiotensin system. Treatment with sufficiently high
doses of vitamin D may represent a promising and inexpensive intervention option. To date,
there are few data on the effect of cholecalciferol treatment in patients with chronic heart
failure. The primary objective of this study is to investigate whether oral vitamin D
supplementation improves chronic heart failure (measured with the surrogate parameter of
NT-proBNP levels at month 0 and 6).
Phase:
Phase 3
Details
Lead Sponsor:
Medical University of Graz
Treatments:
Cholecalciferol Ergocalciferols Vitamin D Vitamins