Vitamin D Supplementation and Acute Respiratory Infection in Older Long-Term Care Residents

• Status: Completed
• Trial end date: 2016-07-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will test the role of high dose vitamin D supplementation in prevention of acute respiratory infection in older nursing home residents. The investigators hypothesize that residents on high dose vitamin D supplementation will have a lower incidence of acute respiratory infection that those on standard dose vitamin D supplementation.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Colorado, Denver
• Collaborators: National Institute on Aging (NIA); The American Geriatrics Society
• Treatments: Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Age 60+ years

• Resides in nursing home

Exclusion Criteria:

• Terminal illness (expected survival <6 months)

• Anticipated discharge within 12 months

• Unable to take whole or crushed tablets

• Active cancer, except squamous/basal cell carcinoma

• Severe malnutrition (body mass index <18 kg/m2)

• Current immunosuppressive medications (including corticosteroids)

• Renal failure (estimated glomerular filtration rate < 15 mL/min/1.73m2)

• Currently taking >1,000 IU/d vitamin D supplementation

• History (or strong family history) of kidney stones

• History of sarcoidosis or other granulomatous disorders associated with hypercalcemia

• Elevated baseline hypercalcemia (albumin-adjusted serum calcium >10.5 mg/dL)

• Baseline serum 25OHD level ≥ 100 nmol/L

• Inability to provide informed consent and no available healthcare legally authorized representative

• Inability of participant or legally authorized representative to speak/understand English