The reason for doing this research is that people with kidney disease often suffer from heart
disease. Why this happens is not fully known. A possible cause may be high blood levels of a
substance made by bacteria called "endotoxin". The blood levels of this substance are high in
people with medium-level kidney disease.
We want to know if replacing normal amounts of Vitamin D can help lower the levels of this
substance. We also want to know if replacing normal amounts of Vitamin D is associated with
other changes that may help heart disease. We hope that our research will help figure out if
levels of this substance can be lowered by replacing normal amounts of Vitamin D. Normal
subjects are enrolled to have a 'control' set for comparison purposes.
Phase:
Early Phase 1
Details
Lead Sponsor:
Rockefeller University
Treatments:
Cholecalciferol Ergocalciferols Vitamin D Vitamins