Vitamin D Regulates the Expression of Glucocorticoid Receptors in Blood of Severe Asthmatic Patients
Status:
Completed
Trial end date:
2014-12-31
Target enrollment:
Participant gender:
Summary
Vitamin D (VitD) deficiency is a significant public health concern in many areas around the
globe which has been associated with many immune-mediated diseases, including asthma. Severe
asthma has been linked with a decreased glucocorticoid receptors (GR) ratio (GR-α/ GR-β
ratio), indicating steroid hyporesponsiveness. Using combined in silico and in vivo
approaches, aimed to explore the immunomodulatory effect of VitD on asthmatic patients
diagnosed with hypovitaminosis D.