Vitamin D Metabolism in Patients With Endocrine Disorders
Status:
Recruiting
Trial end date:
2021-06-01
Target enrollment:
Participant gender:
Summary
This prospective controlled interventional study aims to reveal the diversity of vitamin D
metabolism in patients with certain endocrine disorders (Cushing's disease, acromegaly,
primary hyperparathyroidism, diabetes mellitus type 1) compared to healthy adults. All
patients will receive a single dose (150,000 IU) of cholecalciferol aqueous solution orally.
Laboratory assessments including serum vitamin D metabolites (25(OH)D3, 25(OH)D2,
1,25(OH)2D3, 3-epi-25(OH)D3, 24,25(OH)2D3 and D3), free 25(OH)D, vitamin D-binding protein
(DBP) and parathyroid hormone (PTH) as well as serum and urine biochemical parameters will be
performed before the intake and on Days 1, 3 and 7 after the administration.